Ryan Fitzpatrick turns the ball over twice, and the Chargers walk out with a big win. Yes, it’s Trevor Lawrence’s first start in the NFL, but the number one overall pick looked more than ready for the spotlight in the preseason. Lawrence posted a very solid 78.3 Pro Football Focus offensive grade during his live-action and capped off his preseason by going 11 of 12 for 139 yards and two touchdowns against Dallas. The former Clemson star will be going against arguably the worst team in the NFL and has a great chance to light it up.

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Their coverage includes sports news, previews and predictions, fun facts, and betting. Read More Our BetMGM editors and authors are sports experts with a wealth of knowledge of the sports industry at all levels. With one of the strongest defenses last year at 5th overall, the Steelers are also our favorites to win this game.

The San Francisco 49ers are the biggest favorites in the opening week, having a 7-point edge over the Detroit Lions. The Denver Broncos and Los Angeles Chargers, meanwhile, are the smallest favorites with a one-point edge over the New York Giants and official site Washington Football Team respectively. The oddsmakers released the point spreads and over/unders for each and every game on the schedule. As a result, we already know the full Week 1 schedule and we now know the opening odds — lucky for us gambling degenerates looking to get a headstart on crafting our parlays. The Giants have added Kenny Golladay in free agency and Kadarius Toney in the 2021 NFL Draft to help Daniel Jones in the receiving department.

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Both teams could still score in the mid-20s and the under could hit. That is one of our favorite NFL picks this weekend, so take the Under 52 DraftKings. Both of these defenses are among the worst in the NFL, especially in the secondary. That is why the point total of 52 at most sportsbooks is the second-highest of Week 1.

The good news is that both quarterback Carson Wentz and star guard Quenton Nelson are both officially active for this opener after they both missed the bulk of the summer due to foot injuries. Rookie running back Trey Sermon will not make his regular-season debut today against the Lions with the 49ers electing to hold him out of Sunday’s opener. Sermon was not listed on the Niners injury report at any point this week, which means he’s a healthy scratch for Week 1. The Panthers had no real injury concerns heading into the opener, making five players a healthy scratch to begin the year. Rookie receiver Shi Smith didn’t practice all week due to a shoulder injury and was ruled out on Friday.

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Here’s a side-by-side look at the total number of appearances and records for both the AFC and NFC teams. It was looking like the Colts were cruising to a big road upset as they held a 22-3 lead late in the third quarter. Then Lamar Jackson and the rest of the Baltimore offense came to life. Jackson threw for four TDs from that point, including the game-winner to Marquise Brown in extra time. The Cowboys had their way with the Eagles in a 20-point home win, easily covering as 3.5-point favorites. Dak Prescott threw for three scores while Ezekiel Elliott found the end zone twice on the ground.

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The Cards put up 25 points against the 49ers in a loss in Week 9 last season, and 26 points in a defeat in Week 11; the 49ers allowed 18.5 points per game against their other 14 regular-season opponents. After a dismal 2-6 stretch to close the season that saw them lose each game by double digits and acquire the dreaded “quit on the season” label, it’s no surprise the market is ice-cold on the Jags. But this is a new year, and even with my projected 2.5-point boost for the Colts courtesy of Philip Rivers, the Colts aren’t this much better than the Jags — especially on the road. The Colts’ SRS was -1.8 last season while the Jacksonville’s was -6.7, which would make the Colts 7.4 points better on a neutral field. The Seahawks offense ranked fifth in DVOA last season, 10 spots ahead of the Falcons, who arguably are worse off than a year ago after losing tight end Austin Hooper and wide receiver Mohamed Sanu. And on defense, the Seahawks still project as slightly better than the Falcons after both squads added players on that side of the ball in the first and second round of the draft.

Obviously, the probability of the favorite winning would be 100% less the probability of the underdog winning. The estimated probability of winning uses logistic regression to smooth out the ups and downs. In face, over 3,220 games the over won just two more times than the under. I thought under bets would have performed better, but I’ve been wrong before. Sam Tevi is almost certainly going to be manning Wentz’s blindside in this game.